The homeless disappear. It happens every day in a large city. Have they moved away? Gone into rehab? Died of overdoses and carted away, nameless, to the city morgue? No one seems to care, except a small band of people who live in tents and boxes on the sidewalks. They know their friends have been taken by the Whistlers, animals that hunt in the park to feed their vampire masters. The homeless in the know have escaped from the Whistlers and the vampires, who live in the basement of After Dark, a historic restaurant near the city's new baseball stadium, a hub of city life.

With limited resources, junkies with names like Overboard George, Mad Maggie, and Old Harriet, using an old horror movie fan magazine as a guide, join forces to fight the undead.