Minerva "Minnie" Little has a burning question: where are all the ghosts? When the powerful medium moves to Historic St. Charles, Missouri, the town purported to have the most haunted street in America, she anticipates the spirits inundating her with requests to help with their unfinished business. Instead, she finds no signs of haunting: not a specter, not an orb, not even a faint imprint from a departed soul. For Minnie, the absence of ghosts is spooky.

Worried about the disappearance of a gift she's had since childhood, Minnie searches for the truth about Main Street. She's perplexed to discover a ghosting full of spirits who flee from her presence. Their fear is explained by the appearance of her nemesis from the Institute for Psychical Training and Research -- A medium with an exorcise-first-ask-questions-never philosophy for dealing with the dead. Her former classmate claims to be in St. Charles to save the living from a ghost intent on revenge against the men who killed him.

Minnie's path is clear. All she has to do is convince the local ghosts to trust her, find justice for the vengeful spirit, and thwart her enemy's plan.