Run No More is the story of Avery Lockhart, a gifted young girl who has been on the run for her entire life. Her uncle Finn has spent the last eight years raising her after her mother was killed by the same man they are still running from.

Avery's mother, Luna, was recruited at the age of fifteen by an agency that operates under the guise of training young people with certain gifts so they are able to function normally in society. The real goal of the agency, however, is much more sinister.

The story begins as Avery is about to turn fifteen, the age that her gift comes into full power. She and Finn have just moved to a new town and are trying to stay under the radar. It seems, though, that they have fallen right into the agency's backyard. Avery meets another young girl who also possesses gifts and watches in horror as she is kidnapped by one of the agents right before her eyes. The discovery that Finn's new romantic interest is involved leaves them both terrified.

Desperate to stop running, Avery and Finn develop a plan to rescue Avery's friend and take down the agency. As they execute their plan, things go horribly wrong. Will they make it out alive, or will they be another statistic of the agency?