Three in-depth conversations with the Nobel laureate co-discoverer of the double helix and the first director of the Human Genome Project cover a wide range of topics, including progress in science; the scientist’s role in modern life; women in science; scientific ethics; terrorism; religion; multiculturalism; and how genetics may improve human lives. Reflections by further illustrious contributors to the scientific revolution and the author’s commentaries provide a glimpse into the thinking of scientists who largely determine the progress of humankind in our time.