This volume contains contributions to the XXI International Symposium on Lepton and Photon Interactions at High Energies, held at the Fermi National Accelerator Laboratory. It gives up-to-date reviews of all aspects of particle physics, written by leading practitioners in the field. The review nature of all the articles makes this volume more accessible to students and researchers in other fields of physics. In addition to both new experimental data and data advances in theory, future directions and prospects of the field are covered.