This paper looks at how LDCs can innovate using traditional IPR policies and then looks at how innovation is developing in the informal sector. LDCs have a variety of needs and equally have a variety of IPRs at their disposal to serve their domestic socio-economic and development needs, as well as their international obligations. Companies can choose formal intellectual property, which includes patents, trademarks, registered designs, copyright, among others. They can also choose a range of 'alternative' or informal appropriation mechanisms, such as secrecy, confidentiality agreements, lead time, or complexity. The paper does not attempt to be exhaustive. This paper argues that LDCs need to build at least a critical minimum level of productive capacities and technological capabilities to make full use of the formal and informal IPRs as well as of existing flexibilities. The analysis focuses on six kinds of IPRs and provides case studies based on the experience undertaken in LDCs or in other developing countries.