This Safety Guide provides specific recommendations on core management and fuel handling for research reactors, including handling and storage of fresh fuel, irradiated fuel, core components and neutron sources, to meet the relevant requirements of IAEA Safety Standards Series No. SSR-3, Safety of Research Reactors. The recommendations in this publication are intended for use by operating organizations of research reactors, regulatory bodies and other relevant organizations involved in a research reactor project. This Safety Guide is a revision of IAEA Safety Standards Series No. NS-G-4.3, which it supersedes.