Artificial intelligence (AI) methods have had significant impacts in science and technology in recent years. These methods for generating models from datasets or logic-based algorithms that emulate aspects of human performance can similarly accelerate the fields of nuclear applications, science, and technology toward the IAEA goals of contributing to peace, health, and prosperity. This publication provides a review of the current state of the art, outlines challenges and identifies priorities for future AI activities in the nuclear field and the IAEA’s role to support their accomplishment. The uses of AI in the fields of nuclear sciences and applications, nuclear power, nuclear safety and security and safeguards verification, are considered. There is also a dedicated chapter on ethics pertinent to AI in the nuclear field.