In response to an increase in global activities related to non-water-cooled reactors and small modular reactors, this new Safety Report documenting areas of novelty of these technologies when compared to the current fleet of reactors has been developed. The impact of these areas of novelty on the applicability and completeness of the IAEA safety standards is assessed in the publication. Gaps and areas for additional consideration are identified. The review undertaken to develop this report encompassed the safety standards related to the lifetime of these reactor technologies. The publication also considers the interface between safety, security, and safeguards in the design of these technologies.