This publication reports the results of an IAEA coordinated research project on nuclear data for the production of therapeutic radionuclides. The aim was to provide standardized data for the production of radionuclides for therapeutic purposes, embracing current and possible future needs. Experimental data compilations, theoretical calculations and evaluations were carried out for each of the reactions. The recommendations for production of both established and emerging radionuclides are discussed, and the analysis carried out to produce the recommended data is also presented. The improved quality of the nuclear data will make reactor and accelerator production of therapeutic radionuclides much more efficient, and should also enhance their quality through improved purity of the product. The current publication comprises new evaluated data for both reactor and accelerator production of therapeutic radionuclides based on more than 50 different production reactions.