This publication presents the findings of an IAEA Coordinated Research Project (CRP) on the development and application of the integrated climate, land, energy and water (CLEW) framework. Together with other UN partners, the IAEA has developed this framework in response to global challenges such as ensuring universal access to food, energy and water, to achieve UN Sustainable Development Goals. The publication reflects the objectives of the CRP to expand and improve the knowledge base, tools and toolkits available for integrated assessment of climate, land, energy and water, as well as demonstrate the applicability of these tools in different countries facing diverse challenges. The research results help to identify practical strategies and policies for coherent development and management of land, water and energy resources, and responses to climate change.