This Safety Guide provides guidance on prevailing good practices for meeting, and demonstrating compliance with, the Safety Requirements on Disposal of Radioactive Waste in a systematic and comprehensive manner. It covers aspects related to siting, design, construction, operation and closure, including the safety case, its supporting safety assessments and the regulatory process. The publication addresses both operational and long term safety of geological disposal facilities for wastes that pose a hazard for at least several thousand years. Contents: 1. Introduction; 2. Overview of geological disposal and its implementation; 3. Legal and organizational infrastructure; 4. Safety approach; 5. The safety case and safety assessment; 6. Elements in a stepwise approach to the development of a geological disposal facility; Appendix I: Siting of geological disposal facilities; Appendix II: Post-closure safety assessment.