This Safety Guide is applicable to the predisposal management of radioactive waste derived from the use of radioactive materials in medicine, industry, agriculture, research and education, including disused sealed radioactive sources. It focuses on waste generated at facilities such as hospitals and research centres, where radioactive waste is not usually generated in bulk quantities. It covers the managerial, administrative and technical issues associated with the safe management of radioactive waste, from its generation to its acceptance at a disposal facility or its release from regulatory control.