This publication provides an analysis of results from Integrated Safety Assessment of Research Reactors (INSARR) Missions conducted at research reactors during the period from 1995 to 2021. The analysis includes an assessment of trends, common issues, and other insights that are highly beneficial to Member States operating research reactors. This publication is also useful for self-assessment of research reactor safety. This publication is intended for use by operating organizations of research reactors, regulatory bodies and other relevant organizations involved in the safety of research reactors.