This publication summarizes experience and data relevant to the production of 43/44Sc, 61Cu and 86Y as theranostic pairs to the therapeutic nuclides 47Sc, 67Cu and 90Y. Demand for these radioisotopes is expected to grow in coming years. The publication is meant to give the reader hands on information to select the appropriate nuclide to be used in the imaging application of a theranostic pair. It discusses the different production routes and outlines advantages and disadvantages of direct production versus generator production in some cases. It lists different purification techniques including recovery of the starting material where necessary, and details quality control approaches for the different options.The overall aim is to enable readers involved in radiopharmaceutical production and/or quality control to apply these production approaches in their facilities as part of their respective programmes.