This publication serves as a referencing guide for Member States and interested specialized readers wishing to work on agriculture in dry and saline environment, in particular located in the Middle East region. All information and instructions given in this guide are based on successful and sound practices applied in pertaining Member States for sustainable cropping of salt affected soils. It will help scientists and farmers to select management alternatives most efficient for agriculture in saline environments within their own countries. The publication also focuses on the possible use of isotopes techniques in dealing with salinity and droughts conditions affecting crop production.