Based on a multidisciplinary analysis, the book presents a contemporary view of the main challenges facing regional development and regional policy in Central and Eastern Europe, particularly considering to what extent domestic and non-domestic legacies have affected the regionalization process in this area. The volume mainly focuses on the institutional arrangements at regional level, analyzing the motives, procedures and outcomes of either political or administrative reforms introduced in the latest years. The focus are the former communist countries, both members of the EU and not (case studies selected: Romania, Hungary, Poland and Serbia), with a specific chapter concentrating on a case study from the West - England - whose process of regionalization provides a useful point of reference for the experiences of its Central-East counterparts.