This guide aims to improve the knowledge of healthcare staff, sickle cell patients and their parents about preventive and curative measures for sickle cell disease, with a view to improving the quality of life of sickle cell patients and their survival. It covers the theoretical, preventive and curative aspects of sickle cell disease and the main associated pathologies. We would like sickle cell anaemia to be part of integrated care, so that all providers are able to manage a sickle cell patient, but that all parents are also able to prevent and manage minor crises.