The synthesis of photoluminescent pyrene derivatives and their biomaterial applications in sugar, porphyrin, perylene, and dendrimer systems hold great promise in advancing biomaterial science and technology. They are explored in depth, emphasizing their potential in various biomedical fields. The book discusses their use in biosensing, imaging, drug delivery, and other biomaterial applications. It highlights the advantages offered by each derivative system, such as biocompatibility, stability, and functionalization capabilities, which are essential for their successful integration into biomaterial systems. This book provides a comprehensive analysis of the current state of research in this field, highlighting the potential for these derivatives to contribute to innovative biomaterial applications and pave the way for future advancements.