Actinobacteria, Gram-positive microorganisms found in various environments, are known for producing secondary metabolites and exoenzymes with biotechnological potential. Rhizobacteria, present in symbiosis with legumes, transform atmospheric nitrogen into ammonia, facilitating plant growth. This study co-inoculated strains of both bacterial groups isolated from the northeastern semi-arid region to investigate the influence of actinobacteria on rhizobial growth. Ten strains of actinobacteria and seven of rhizobacteria were selected, morphologically characterized and submitted to co-inoculation in culture media. The growth of the rhizobacteria was evaluated, showing a positive interaction, suggesting that the exoenzymes of the actinobacteria facilitate the metabolism of complex substrates by the rhizobacteria. This promising interaction could lead to the development of new bioinoculants to promote plant growth.