Regenerative medicine is a developed field in which diseased tissues and organ are restored or regenerated. This interdisciplinary field converges biomedical research, technology and clinical care, which is based on the concept of employing intrinsic repair mechanisms within the tissue itself. The clinical use of stem cell is an hallmark of regenerative medicine, that can be manipulated both endogenous progenitor population in situ or autologous and allogeneic stem cells transplantation. Recent epoch in human stem cell therapy is highly valuable and this phenomenon is now also entering the veterinary field.Hepatic progenitor cells (HPCs) are a reserve compartment of progenitor and adult stem cells. Hepatic progenitor cells are a reserve compartment of adult stem or progenitor cells that reside within the liver and are found in rodents, humans, dogs and cats. Efficacy of liver-derived allogenic hepatocyte stem cells in the repair of hepatic damage with following objective to collect, isolate and propagate liver-derived multipotent stromal cellings (L-MSCs). Investigate the therapeutic potential of hepatocytic stem cells for augmenting the healing of hepatic damage.