Formulation of a soluble drug insert of famciclovir for novel drug delivery containing the natural hydrophilic polymer hydroxypropyl cellulose and hydrophobic polymer ethyl cellulose using the solvent casting method. Increased contact time, controlled release, decreased frequency of administration, increased patient compliance, and greater therapeutic efficacy. Formulation F2 containing famciclovir and 4 mg hydroxy propyl cellulose sandwiched between ethylcellulose as a polymer satisfied the required pharmaceutical characteristics of ocular inserts and was found to be promising. From the in vitro diffusion study, it was concluded that the F2 formulation showed a greater release of 98.99% with controlled characteristics at 8 h when compared to other formulations.