Understanding the clinical evolution of Sickle Cell Anaemia

Aylla Nubia L M Da Silva Dos Santos, Greice de Lemos Cardoso Costa

Understanding the clinical evolution of Sickle Cell Anaemia
Format
Paperback
Publisher
Our Knowledge Publishing
Published
12 May 2024
Pages
80
ISBN
9786207532674

Understanding the clinical evolution of Sickle Cell Anaemia

Aylla Nubia L M Da Silva Dos Santos, Greice de Lemos Cardoso Costa

Sickle cell anaemia is a disease that has direct implications for the vascular environment due to the polymerisation of haemoglobin S inside the erythrocyte, making them sickle and rigid. The two main phenomena that occur in FA, intravascular haemolysis and vaso-occlusion, generate disturbances in the vasculature of these patients and are responsible for a series of clinical complications. However, vaso-occlusion is a determining factor in clinical evolution, as the endothelium is responsible for vascular homeostasis, and any factor that could upset the balance, such as sickle cell erythrocytes occluding the vessels, triggers a cascade of pathophysiological events. In view of this, our aim was to investigate the influence of genetic polymorphisms that are directly or indirectly involved in vaso-occlusive processes on the clinical variability of sickle cell anaemia.

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