Recent attention has been focused on techniques addressing green chemistry principles in order to create safer and more sustainable organic synthesis processes. With this strategy, new, longer-lasting catalysts, solvents, more atom-efficient processes, and chemicals that are more ecologically friendly are used. Multicomponent reactions (MCRs) are synthetic reactions that involve the simultaneous reaction of three or more starting materials to yield a single product. Green chemistry principles can be applied to MCRs to minimize their environmental impact and improve their sustainability. In the context of MCRs, green chemistry principles can be applied in several ways. For example, the use of starting materials that are renewable, non-toxic, and have minimal impact on the environment. Renewable starting materials are those that come from sustainable sources and can be replenished over time. By using renewable starting materials, we can reduce our dependence on fossil fuels and create a more sustainable future. Moreover, by using non-toxic starting materials, we can reduce the risk of exposure to harmful chemicals and create a safer working environment for chemists and other workers.