Periodontitis is an inflammatory disease, often of multifactorial etiology in which the perio - pathogenic bacterial biofilm plays an important role. The disease is characterized by an inflammatory reaction of the host to the bacterial aggression, reactions on which both local and systemic risk factors can be grafted. Barrier membranes are designed to promote tissue regeneration and can be divided according to the biodegradability of the base material. In recent years, the use of biodegradable membranes has been mainstreamed in GBR, however non-biodegradable products are often applied to massive tissue loss and vertical bone defects owing to their advantages in space making. The field of barrier membranes is expanding, and the evolution of biomaterials is inevitable.