Study on tissue injury following high-voltage shock helps reduce amputation rate. This book provides an overall assessment of skin under different dosages of direct current high-voltage electrical shock, through optical imaging modality and simulation. Electrical injuries are examined by a Spatial Frequency Domain Imaging (SFDI) system on physiological parameters which reveals the viability of skin tissues distant to the wounds. These information shows the correlation to the alteration of blood perfusion, measured by a Laser Doppler Imaging machine, and thermal damage level due to electrical and thermal distributions, which simulated by a novel finite element model for a 3D rat. The novel application of SFDI in burn wound assessment was again proved with the recognition of infection of the wounds which help in early infection detection for systemic complication reduction. In order to minimize the drawbacks of SFDI in curved surface imaging, a practical correction method for phantom reconstruction with any shape is also introduced which combines 3D printing and 3D imaging methods. Such a correction method can also be applied to other spectral imaging modalities.