Apoptose no carcinoma colo-retal: IAPs e SMAC
Flavio de Oliveira Lima,Celina Oshima,Marcello Franco
Apoptose no carcinoma colo-retal: IAPs e SMAC
Flavio de Oliveira Lima,Celina Oshima,Marcello Franco
This title is printed to order. This book may have been self-published. If so, we cannot guarantee the quality of the content. In the main most books will have gone through the editing process however some may not. We therefore suggest that you be aware of this before ordering this book. If in doubt check either the author or publisher’s details as we are unable to accept any returns unless they are faulty. Please contact us if you have any questions.
Objetivos: Avaliar a imuno-expressao de Survivina, XIAP, cIAP-1, cIAP-2 e SMAC/DIABLO em tecido tumoral e mucosa nao tumoral adjacente ao tumor de pacientes com cancer colo-retal, nao submetidos a radio ou quimioterapia. Correlacionar os resultados com o Indice Apoptotico, Proliferacao Celular e imuno-expressao da proteina p53 nestes mesmos tecidos, e com o prognostico dos pacientes. Metodo: Foi confeccionado um bloco de parafina de TMA com tecido de cancer colo-retal e da mucosa adjacente de 130 pacientes operados no Hospital Sao Paulo da EPM/UNIFESP, de 2002 a 2005, nao submetidos a radio ou quimioterapia. Cortes de 4 m do bloco de TMA foram submetidos a reacao imuno-histoquimica para survivina, XIAP, cIAP-1, cIAP-2 e SMAC. As laminas foram lidas independentemente por tres patologistas experientes, sendo obtidos escores de intensidade de imunoexpressao. Esses escores foram correlacionados entre si e com o IA obtido com o uso dos anticorpos anti-caspase 3 clivada e M30 (citoqueratina 18 clivada), indice de proliferacao celular, imunoexpressao da proteina p53 e dados de sobrevida dos pacientes.
This item is not currently in-stock. It can be ordered online and is expected to ship in 7-14 days
Our stock data is updated periodically, and availability may change throughout the day for in-demand items. Please call the relevant shop for the most current stock information. Prices are subject to change without notice.
Sign in or become a Readings Member to add this title to a wishlist.