The Nurnberg Metropolitan Region is one of the most powerful economic regions in Europe. Several renowned multinational corporations, like Adidas, Puma, Schaeffler and Siemens, as well as many impressive family-owned firms and hidden champions are headquartered here. This volume contains 18 case studies of companies and their international operations. The scope of this volume extends from the early internationalization strategies in the Middle Ages to the consequences of the COVID-19 pandemic and the Russian war against Ukraine on current business activities. The case studies cover an extensive range of topics from market entry strategies, marketing activities and human resource management to corporate social responsibility.