The emergence of global knowledge societies questions the meaning and relevance of local knowledge in the context of Southern countries. Women have proven to be the central actors in the multiple channels of local-global networking, using these new social ties for the negotiation of old and new elements of knowledge, scientific knowledge, and development discourses. The inherent politicization of knowledge and the direct objective of transforming societal institutions are not only signs of resistance against global hegemony, but serve for a new definition and for a defense of local culture and of local knowledge.