This Special Issue of Axioms entitled "Mathematical Methods in Applied Sciences" includes 17 articles and an editorial. These articles explore a wide range of topics in applied mathematics, from pure mathematical methods to applied methods in various scientific fields. This Special Issue emphasizes several fields, such as mathematical methods and analysis, statistical methods, natural language processing, neural networks, numerical methods, and fuzzy systems. The objective of this Special Issue is to provide a platform for scholars to publish their recent work, delve deeper into various problems, and solve them mathematically.