Diabetic foot is a growing complication due to the global increase in diabetes mellitus prevalence; this disease affects 9.1 to 26.1 million people annually, and between 19% and 34% of people develop diabetes at least once in their life. Diabetic foot is sometimes associated with lower limb amputations and higher rates of mortality than certain types of cancer, such as breast or prostate cancer. In recent years, research has focused on managing the main complications that lead to limb loss, such as diabetic foot infections or peripheral vascular disease. The majority of studies have investigated the outcomes in the acute phase when the patient has a complicated diabetic foot ulcer. However, long-term studies, randomized control trials, and studies on prevention, both primary and secondary, are still scarce in the literature. In addition, the benefits of multidisciplinary teams on patient outcomes, health care system organization, the competences of different specialities and health care professionals, and the impact of different organizational and structural approaches are not yet well studied. This Special Issue discusses the current state of the art, addresses ongoing knowledge gaps, and focuses on ongoing controversies related to diabetic foot complications.