Once a central topic of philosophy of science, scientific explanation attracted less attention around the turn of the century. In recent years the subject reemerges in various ways on the working agenda. My aim in this book was to argue for a new sort of approach towards the topic. Taken into account the drawbacks of the previous conceptions but also the tendencies in actual research, I argue for a local, dynamic and non-theory driven kind of approach as the most promising one. Reference to models and the modeling processes would provide the frame for the articulation of such a view.