This book proposes a catholicon inferred from Alfred North Whitehead’s Imaginative Generalization, to the age long scuffle between Religion and Science. It traces the history of the disagreement, between these areas of human progress, back to the Southern Reformation, thereby establishing and substantiating the thesis that the tussle after all, is not in any way recent. This perspective is seldom explored by scholars on the debate. The book also chronicles and then debunks the three contemporary approaches (inevitable conflict; independence; and the potential conflict) to the divergence as inadequate and misleading. Substance metaphysics is also suspect. With its many pursuivants and bifurcation of nature, substance metaphysics diminishes the chances for an elixir. In this regard, this study endorses naturalistic panentheism and argues for its feasibility on the rapproachment between the seemingly antagonistic fields. Drawing heavily from the Philosophy of Organism, naturalistic panentheism not only quells the series of sempiternal discourses on the clash, but also reveals the senselessness and otiosity in inter-religious/faith crises, alongside a batten panacea for theodicy.