Membrane Defenses Against Attack by Complement and Perforins
Membrane Defenses Against Attack by Complement and Perforins
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In this volume a comprehensive review of membrane proteins that regulate
complement and perforin-mediated cytolysis is presented. A detailed analysisis provided of the biochemical, molecular, and functional features of
these proteins; the glycosyl phosphatidylinositol linked proteins are
covered, with emphasis placed on the functional importance of this type of membrane anchor. Further chapters include reviews of the effects of
complement activation on cells that are metabolically active, and of the
regulation of cell killing by cytotoxic lymphocytes, considering
the similarities and disparities between the complement and perforin
systems. The therapeutic use of recombinant CR1 for immune-mediated
pathophysiological processes is discussed in a separate section.
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