This book provides a new collection of papers on applied regional science. It takes each of the main methodologies of the discipline and provides a case study of their use for policy making. The work reported in each chapter has been directly funded by the private sector or by major Government departments. Thus it shows how important the methodologies of regional science can be for problem solving. Each chapter describes the methodology itself, the client requirements, the data sources used, the results and any new theoretical developments arising from the applications. These case studies show how the discipline has matured and how it is now capable of providing answers to a wide range of what-if scenarios.