Zlokachestvennaya Arterial'naya Gipertenziya
Teplova N V,Taratukhin E O
Zlokachestvennaya Arterial'naya Gipertenziya
Teplova N V,Taratukhin E O
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Monografiya posvyashchena issledovaniyu bol'nykh zlokachestvennoy refrakternoy k terapii arterial'noy gipertenziey. Polucheny novye dannye o patogeneze gemodinamicheskikh narusheniy pri zlokachestvennoy pervichnoy arterial'noy gipertenzii, soglasno kotorym tyazheloe techenie i rezistentnost’ k provodimoy mnogokomponentnoy terapii v osnovnom svyazany s remodelirovaniem levogo zheludochka serdtsa, aorty i ee vetvey v neskol'kikh sosudistykh basseynakh, s formirovaniem rezistivnogo tipa gemodinamiki pri vysokom urovne obshchego perifericheskogo soprotivleniya krovotoku. V issledovanii ustanovlena znachimost’ ryada gemodinamicheskikh, metabolicheskikh, elektrolitnykh, gormonal'nykh i belkovykh narusheniy, prepyatstvuyushchikh gipotenzivnomu deystviyu kombinirovannoy terapii. Po rezul'tatam mnogofaktornogo analiza predlozhen algoritm korrektsii mekhanizmov, snizhayushchikh effektivnost’ gipotenzivnogo lecheniya u takikh bol'nykh. Vydeleny gruppy gipotenzivnykh preparatov, okazyvayushchikh naibolee vyrazhennoe deystvie v zavisimosti ot urovnya soderzhaniya v krovi endogennogo relaksiruyushchego faktora - oksida azota.
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