The degenerative effect of sickle cell disease (SCD) makes it one of the most challenging molecular disease globally. Various treatment regimen are neither accessible nor affordable in developing countries where they are mostly needed. This work provides a succor, owing to the simplified protocols in this text. The study offers Researchers, Pharmaceutical professionals, Academicians and graduate students the opportunity of reproducing the research using already laid down Bio-marker Assays contained in this book. This will help in the development of SCD drugs that will be readily accessible and affordable. This book encompasses assays of clinical conditions that makes sickle cell disease much more terminal. Methemoglobin levels have recently been on the rise among SCD patients in Sub-Saharan Africa. Furthermore, erythrocytes’-membrane tend to become frailer in some patients, suggesting a new dimension the disease is usurping. This research therefore reveals that both crude and partially purified leaves, seeds and stem of Telferia occidentalis portends a great promise in ameliorating frail erythrocytes while inhibiting methemoglobin buil-up in Sickle Cell Disease.