Acute Promyelitic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy
Acute Promyelitic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy
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Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
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