The Special Issue entitled "Data Mining and Machine Learning with Applications" aimed to connect researchers in the fields of deep learning, artificial intelligence, data mining, and machine learning. Included within this reprint are all the accepted articles that were published in the Special Issue. It is our hope that readers can benefit from the valuable insights presented in these papers, ultimately contributing to the advancement of these rapidly expanding areas. Furthermore, we believe that this Special Issue will shed light on major developments in machine learning and data mining, drawing the attention of the scientific community towards further investigations that will expedite the implementation of these techniques.