Volume 42 of Progress in Drug Research contains seven reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with organization and management of drug research; luteinizing hor mone regulators; natural products as anticancer agents; flavonoids and their pharmacological activity; serenics in the control of mental disturbances; Transfer Factor and its application and with Transfer Factor in malignancy. In the 34 years that Progress in Drug Research has existed, the Edi tor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the review ers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate informa tion on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the non-specialists, who can obtain an overview of a particular field of drug research in a rela tively short time.