For a long time we have naively talked about the Middle Ages, the Renaissance, and other periods, but at closer analysis all those terms prove to be constructed models to help us understand in rough terms profound changes that affected human conditions throughout time. As the contributions to the present volume indicate, paradigm shifts have occurred regularly and constituted some of the critical developments in human existence. The notion of paradigm shift as first developed by Thomas Kuhn is here considerably expanded to address also literary, religious, scientific, and cultural-historical phenomena, to deal with contrasting conceptions of various parts of the world (China versus Europe), conflicts between genders, economic changes pertaining to women’s roles, social and political criticism, models of how to explain our existence, ideological positions and epistemological approaches. The study of paradigm shifts makes it possible to grasp fundamental movements both horizontally (the present world in global terms) and vertically (from the past to the present), exposing thereby central forces leading to shifts in power structures and in the mental-historical world-views. Focusing on paradigm-shifts allows us to gain deep insight into conflicting discourses throughout time and to illuminate the struggle between dominant and competing models explaining or determining reality.