In recent years, humanity has experienced dramatic advances in medicine, science, and technology. But we also face unprecedented challenges, including deadly conflicts, major disasters, and even global pandemics. Importantly, the modern human experience has demonstrated the awesome power of scientific principles to dramatically improve health and extend life. We’ve also created the internet along with powerful computers, mobile devices, and robots. It is therefore worth exploring the idea that these scientific principles may also help humanity to overcome these unprecedented challenges facing humanity. By analyzing major scientific principles of chemistry, biology, physics, and statistics, we can apply their relevance to human traits, the interaction between humans and nature, and the interaction among humans. The Destiny of Humanity crystallizes a unifying moral compass that is compatible with advanced science and technology to guide the application of powerful emerging technologies. It aims to elicit a new way of thinking about the grave challenges facing humanity.