In 1700, a great wave sinks entire islands in the Puget Sound, leaving a three-year-old indigenous girl the sole survivor. A medicine woman on a distant island, Ama, finds and raises the child as WolfShe and trains her in healing arts. WolfShe grows into a powerful medicine woman, one haunted by the loss of her family. Not knowing her totem, she fears no ancestors will greet her at the gate to the Land of Mists when she dies. Without their help she could be forever lost in the Land of Shadow Fog. Pale Face, an invader and trapper, hunts WolfShe and her wolf. But he carries a more terrible threat than his knife, a disease that kills. In trying to escape him, WolfShe discovers her fate as a healer and her true totem.