Endometrial cancer is the most common gynecological malignancy in women in developed countries. Most cases are generally diagnosed at an early-stage and curable with loco-regional therapies. Metastatic and/or recurrent disease still remains a therapeutic challenge and clearly represents an unmet medical need. Substantial progress has been made over the last decade in different fields of Gynecologic Oncology that has translated into a better understanding of the biology and clinical behavior of endometrial cancer and its management. Hence, this monograph provides a current overview of endometrial cancer spanning from its clinical epidemiology to molecular cancer therapeutics. The most relevant clinical aspects such as imaging, new surgical and radiation techniques, and the role of endocrine therapy and chemotherapy in the systemic treatment of endometrial cancer will also be discussed. With the contribution of internationally well-renowned experts in the field, this book will keep the reader abreast of the most recent advances in endometrial cancer from a multi-disciplinary perspective. This monograph is highly recommended for OB/GYN residents and fellows, nurse practitioners, junior faculty and all those interested in the field of women’s cancer.