The book discusses the management of Langerhans cell histiocytosis (LCH)-induced central diabetes insipidus and the related endocrinological/neurological sequelae. Organ transplants have slowly grown across the world and for the maintenance of apt potential organs, AVP is required. Moreover, nephrogenic DI, the potential therapeutic drugs and overview of membrane protein stability is also elucidated along with presentation of novel insights into the diagnosis and management of pregnancy-related DI. Further it provides information regarding the complications with differential diagnosis in a case of central DI in a female patient with bipolar disorder. Finally, over the past few years, the development of MRI imaging on the pituitary gland with the hypothalamus and stalk has progressed. The book also comprehensively discusses the imaging methodologies in DI.