Melanomas are usually highly proliferative, invasive and are most frequently metastatic. Melanoma accounts for nearly 4% of skin cancer cases but, because of its highly metastatic capability, for 74% of all skin cancer mortalities. Therefore, melanoma is one of the deadliest forms of cancer and its treatment continues to be challenging. This book presents topical research in the study of the symptoms, diagnoses and treatment of metastatic melanoma. Topics discussed include new therapeutic alternatives for melanoma; the metastatic cascade and experimental treatments; pediatric melanoma and the relative risk of metastatic melanoma.