Antonio Gramsci’s The Southern Question remains as provocative today as it was when it was written. During ten years of political imprisonment under Mussolini’s Fascist government, Gramsci produced The Prison Notebooks, a continued meditation on subjects and relationships first proposed within the pages of this essay. The purpose in re-introducing the essay is to emphasize how Gramsci’s analysis of social stratification of Northern and Southern Italy in 1926 is relevant to current discussions about state formation, diasporas, and strategic alliances.