Once called the four-headed monster in high school, only to be decapitated by the disaster of coupling up, four childhood friends have healed their wounds and found their way back to each other in college-or so they thought. Now, months before they enter the "real" world, decapitation once again is imminent by way of: a rejected proposal, a birth control fail, an almost menage a quartet, and a secret (and-thought-to-be-impossible) hook-up. Everything explodes over the course of a Christmas vacation in Florida, leaving the survival of these four friendships, once again, on the brink.