Mama's Girls tells the story of a married woman turned single mother of five. All five of her daughters have very different personalities even in their youth. Mama has to find ways to balance meeting the needs of all five of her children, especially her youngest, Sonya, who is a part of a secret that she has no idea about. As the girls grow up, they begin to focus on their own needs and eventually delve deeper into their own lives. Sonya remains close to Mama; however, she denies herself a personal life to make sure that Mama is okay. She's beginning to feel overwhelmed, and then one day, Mama has an accident. Sonya calls her sisters and asks them to come see Mama and help her get through this tough time. Will all of Mama's girls show up?