Gerardo Ceballos, Anne H. Ehrlich, and Paul R. Ehrlich serve as witnesses in this trial of human neglect, where the charge is the massive and escalating assault on living things. Nature is being annihilated, not only because of the human population explosion, but also as a result of massive commercial endeavors and public apathy. Despite the well-intentioned work of conservation organizations and governments, the authors warn us that not enough is being done and time is short for the most vulnerable of the world’s wild birds and mammals. Thousands of populations have already disappeared, other populations are dwindling daily, and soon our descendants may live in a world containing but a minuscule fraction of the birds and mammals we know today. The Annihilation of Nature is a clarion call for engagement and action. These outspoken scientists urge everyone who cares about nature to become personally connected to the victims of our inadequate conservation efforts and demand that restoration replace destruction. Only then will we have any hope of preventing the worst-case scenario of the sixth mass extinction.